Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.39 |
| ▸ | AGER | Q15109 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.36 |
| ▸ | SFRP1 | Q8N474 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782721 | 0.92 | NR1H2 (0.41) | NR1H2ADAMTS4GRIA2ALDH1A1HTR1A | |
| SCHEMBL4783187 | 0.86 | NR1H2 (0.44) | NR1H2ADRB3ADRB1ADAMTS4AGER | |
| SCHEMBL4783485 | 0.85 | NR1H2 (0.54) | NR1H2ADRB3ADRB1AGERTSHR | |
| SCHEMBL4783419 | 0.83 | NR1H2 (0.43) | NR1H2GRIA2 | |
| SCHEMBL4783415 | 0.81 | NR1H2 (0.41) | NR1H2GRIA2 | |
| SCHEMBL4907973 | 0.80 | NR1H2 (0.46) | NR1H2ADRB3ADRB1TSHRALOX15 | |
| SCHEMBL4783093 | 0.79 | PSEN1 (0.43) | NR1H2ADRB3ADRB1TSHRALOX15 | |
| SCHEMBL4784110 | 0.78 | TRPV4 (0.43) | NR1H2GRIA2SFRP1IDH1 | |
| SCHEMBL4783995 | 0.78 | NR1H2 (0.43) | NR1H2GRIA2HTR1AHTR7SFRP1 | |
| SCHEMBL4781466 | 0.78 | NR1H2 (0.47) | NR1H2ADAMTS4SFRP1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061006-A1 | SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |