Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 14/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4784239 | 0.91 | MEN1 (0.48) | KMT2AMEN1ALDH1A1TSHRGAA | |
| SCHEMBL4781216 | 0.87 | TBXAS1 (0.47) | TBXAS1TBXA2R | |
| SCHEMBL4780521 | 0.86 | TBXAS1 (0.48) | TBXAS1TBXA2RALDH1A1TSHR | |
| SCHEMBL4782630 | 0.85 | KMT2A (0.48) | TBXAS1KMT2AMEN1TBXA2RALDH1A1 | |
| SCHEMBL4783865 | 0.84 | TBXAS1 (0.48) | TBXAS1TBXA2RALDH1A1GAA | |
| SCHEMBL4783444 | 0.84 | TBXAS1 (0.48) | TBXAS1TBXA2R | |
| SCHEMBL4785654 | 0.83 | TBXAS1 (0.46) | TBXAS1TBXA2RALDH1A1 | |
| SCHEMBL4783077 | 0.82 | TBXAS1 (0.46) | TBXAS1KMT2ATBXA2RNAMPT | |
| SCHEMBL4782361 | 0.82 | TBXAS1 (0.46) | TBXAS1KMT2AMEN1TBXA2RNAMPT | |
| SCHEMBL4785858 | 0.76 | MEN1 (0.62) | KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |