Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 15/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4784929 | 0.91 | ALDH1A1 (0.45) | ALDH1A1HTT | |
| SCHEMBL4782569 | 0.90 | TDP1 (0.51) | SMN1; SMN2TDP1ALDH1A1HTT | |
| SCHEMBL4780521 | 0.88 | TBXAS1 (0.48) | TBXAS1TBXA2RSMN1; SMN2TDP1ALDH1A1 | |
| SCHEMBL4781216 | 0.87 | TBXAS1 (0.47) | TBXAS1TBXA2RSMN1; SMN2TDP1 | |
| SCHEMBL4783865 | 0.86 | TBXAS1 (0.48) | TBXAS1TBXA2RSMN1; SMN2TDP1ALDH1A1 | |
| SCHEMBL4783444 | 0.86 | TBXAS1 (0.48) | TBXAS1TBXA2RSMN1; SMN2TDP1 | |
| SCHEMBL4780287 | 0.85 | ALDH1A1 (0.48) | TDP1ALDH1A1 | |
| SCHEMBL4782361 | 0.84 | TBXAS1 (0.46) | TBXAS1TBXA2RSMN1; SMN2TDP1 | |
| SCHEMBL4783077 | 0.84 | TBXAS1 (0.46) | TBXAS1TBXA2RSMN1; SMN2TDP1 | |
| SCHEMBL4782431 | 0.84 | HTT (0.43) | TDP1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |