Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.45 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5401965 | 0.84 | HSD11B1 (0.48) | HSD17B10L3MBTL1HSD11B1CYP2C9EPHX2 | |
| SCHEMBL16698251 | 0.70 | HSD11B1 (0.48) | HSD17B10L3MBTL1HSD11B1CYP2C9 | |
| SCHEMBL160953 | 0.70 | HSD11B1 (0.48) | HSD17B10L3MBTL1HSD11B1CYP2C9 | |
| SCHEMBL19859959 | 0.70 | HSD11B1 (0.48) | HSD17B10L3MBTL1HSD11B1CYP2C9 | |
| SCHEMBL27284428 | 0.70 | HSD11B1 (0.52) | HSD17B10L3MBTL1HSD11B1CYP2C9EPHX1 | |
| SCHEMBL2181379 | 0.70 | HSD11B1 (0.46) | HSD17B10L3MBTL1HSD11B1CYP2C9EPHX1 | |
| SCHEMBL177210 | 0.69 | HSD11B1 (0.45) | HSD17B10L3MBTL1HSD11B1CYP2C9EPHX2 | |
| Hydrochloric Acid SCHEMBL3051989 | 0.69 | HSD11B1 (0.46) | HSD17B10L3MBTL1HSD11B1CYP2C9 | |
| SCHEMBL813578 | 0.69 | HSD11B1 (0.45) | HSD17B10L3MBTL1HSD11B1CYP2C9EPHX1 | |
| SCHEMBL31349739 | 0.69 | HSD11B1 (0.46) | HSD17B10L3MBTL1HSD11B1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008035049-A1 | ADAMANTANYL-(CYCLOPROPYL)-KETONES AS METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2008-03-27 | — | — | WO | disclosed |
| WO-2008035049-A1 | ADAMANTANYL-(CYCLOPROPYL)-KETONES AS METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2008-03-27 | — | — | WO | disclosed |