Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 6/20 | 0.33 |
| ▸ | WNT3A | P56704 | 6/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.32 |
| ▸ | CLK1 | P49759 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.30 |
| ▸ | BRD1 | O95696 | 1/20 | 0.30 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5069134 | 0.85 | CTSL (0.34) | BACE1NPC1RAB9A | |
| SCHEMBL5136499 | 0.81 | KCNH2 (0.31) | BACE1 | |
| SCHEMBL4517752 | 0.80 | CNR1 (0.38) | CTNNB1WNT3ACTSDBACE1BACE2 | |
| SCHEMBL4511507 | 0.74 | BACE1 (0.42) | CTSDBACE1BACE2CLK1DYRK1A | |
| SCHEMBL5139355 | 0.70 | BACE1 (0.51) | CTNNB1WNT3ACTSDBACE1BACE2 | |
| SCHEMBL4526528 | 0.69 | BACE1 (0.64) | CTSDBACE1BACE2 | |
| SCHEMBL4913957 | 0.68 | CNR1 (0.44) | CTSDBACE1BACE2NPC1ALDH1A1 | |
| SCHEMBL4785933 | 0.67 | CNR1 (0.38) | CTSDBACE1BACE2 | |
| SCHEMBL4854354 | 0.66 | LMNA (0.50) | CTNNB1WNT3ACLK1DYRK1ADYRK1B | |
| SCHEMBL8185847 | 0.66 | NOTUM (0.47) | CTNNB1WNT3ACLK1DYRK1ADYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076044-A1 | NOVEL 2-AMINO-5, 5-DIARYL-IMIDAZOL-4-ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |