Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 7/20 | 0.54 |
| ▸ | WNT3A | P56704 | 7/20 | 0.54 |
| ▸ | MAOB | P27338 | 2/20 | 0.49 |
| ▸ | PRKCI | P41743 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | PIR | O00625 | 1/20 | 0.37 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | GPR183 | P32249 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4783710 | 0.92 | MAOB (0.51) | CTNNB1WNT3AMAOBPRKCICES2 | |
| SCHEMBL4518583 | 0.80 | CTNNB1 (0.59) | CTNNB1WNT3AMAOBPRKCICLK1 | |
| SCHEMBL8192501 | 0.79 | ERN1 (0.47) | CTNNB1WNT3AMAOBPRKCICLK1 | |
| SCHEMBL11239661 | 0.79 | CTNNB1 (0.63) | CTNNB1WNT3APRKCICLK1DYRK1A | |
| SCHEMBL4737812 | 0.76 | PKM (0.43) | MAOBCES2CES1MAPTNPC1 | |
| SCHEMBL4737265 | 0.76 | CTNNB1 (0.39) | CTNNB1WNT3AMAOBPRKCICLK1 | |
| SCHEMBL875455 | 0.75 | CTNNB1 (0.67) | CTNNB1WNT3APRKCICLK1DYRK1A | |
| SCHEMBL31262479 | 0.75 | CTNNB1 (0.67) | CTNNB1WNT3APRKCICLK1DYRK1A | |
| SCHEMBL8319676 | 0.74 | PRKCI (0.63) | CTNNB1WNT3APRKCICLK1DYRK1A | |
| SCHEMBL1726294 | 0.74 | CTNNB1 (0.61) | CTNNB1WNT3APRKCICLK1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076044-A1 | NOVEL 2-AMINO-5, 5-DIARYL-IMIDAZOL-4-ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008076044-A1 | NOVEL 2-AMINO-5, 5-DIARYL-IMIDAZOL-4-ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008076043-A1 | NOVEL 2-AMINO-5,5-DIARYL-IMIDAZOL-4-ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008076043-A1 | NOVEL 2-AMINO-5,5-DIARYL-IMIDAZOL-4-ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |