Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 2/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.41 |
| ▸ | WNT3A | P56704 | 3/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PRKCI | P41743 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | NAAA | Q02083 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8191121 | 0.82 | ERN1 (0.47) | ERN1NOTUMDYRK1AMAPTRAB9A | |
| SCHEMBL4737265 | 0.81 | CTNNB1 (0.39) | ERN1NOTUMDYRK1AMAPTRAB9A | |
| SCHEMBL4784686 | 0.79 | CTNNB1 (0.54) | ERN1DYRK1AMAPTRAB9ANPC1 | |
| SCHEMBL19188065 | 0.78 | NOTUM (0.50) | ERN1NOTUMDYRK1AMAPTRAB9A | |
| SCHEMBL4354029 | 0.77 | SMN1; SMN2 (0.39) | NOTUMDYRK1ARAB9ANPC1CTNNB1 | |
| SCHEMBL14576619 | 0.77 | CTNNB1 (0.38) | NOTUMDYRK1ACTNNB1WNT3ACLK1 | |
| SCHEMBL8185847 | 0.77 | NOTUM (0.47) | ERN1NOTUMDYRK1AMAPTRAB9A | |
| SCHEMBL16574214 | 0.74 | NOTUM (0.50) | ERN1NOTUMDYRK1AMAPTRAB9A | |
| SCHEMBL21998756 | 0.74 | DYRK1A (0.51) | ERN1NOTUMDYRK1AMAPTRAB9A | |
| SCHEMBL27578676 | 0.74 | ERN1 (0.50) | ERN1NOTUMDYRK1AMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076044-A1 | NOVEL 2-AMINO-5, 5-DIARYL-IMIDAZOL-4-ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |