Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 7/20 | 0.39 |
| ▸ | WNT3A | P56704 | 7/20 | 0.39 |
| ▸ | ACACB | O00763 | 3/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | PRKCI | P41743 | 1/20 | 0.34 |
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.33 |
| ▸ | CHRNG | P07510 | 1/20 | 0.33 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | CHRND | Q07001 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8192501 | 0.81 | ERN1 (0.47) | CTNNB1WNT3ACLK1DYRK1ADYRK1B | |
| SCHEMBL4521301 | 0.79 | ACACB (0.40) | CTNNB1WNT3AACACBCLK1DYRK1A | |
| SCHEMBL4784686 | 0.76 | CTNNB1 (0.54) | CTNNB1WNT3ACLK1DYRK1ADYRK1B | |
| SCHEMBL4354029 | 0.74 | SMN1; SMN2 (0.39) | CTNNB1WNT3ACLK1DYRK1ADYRK1B | |
| SCHEMBL14576619 | 0.74 | CTNNB1 (0.38) | CTNNB1WNT3ACLK1DYRK1ADYRK1B | |
| SCHEMBL4737647 | 0.74 | ACACB (0.42) | CTNNB1WNT3AACACBCLK1DYRK1A | |
| SCHEMBL97687 | 0.72 | DYRK1A (0.47) | CTNNB1WNT3AACACBCLK1DYRK1A | |
| SCHEMBL4849472 | 0.72 | DYRK1A (0.43) | CTNNB1WNT3AACACBCLK1DYRK1A | |
| SCHEMBL4734542 | 0.72 | DYRK1A (0.43) | CTNNB1WNT3AACACBCLK1DYRK1A | |
| SCHEMBL10317153 | 0.72 | CLK1 (0.43) | CTNNB1WNT3AACACBCLK1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076044-A1 | NOVEL 2-AMINO-5, 5-DIARYL-IMIDAZOL-4-ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008076043-A1 | NOVEL 2-AMINO-5,5-DIARYL-IMIDAZOL-4-ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |