Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 15/20 | 0.49 |
| ▸ | SMO | Q99835 | 5/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4736966 | 0.90 | NR3C1 (0.58) | NR3C1PGRCYP3A4CYP2C9 | |
| SCHEMBL4737912 | 0.78 | NR3C1 (0.72) | NR3C1SMOPGRCYP3A4CYP2C9 | |
| SCHEMBL4737072 | 0.75 | SMO (0.42) | SMO | |
| SCHEMBL4114088 | 0.74 | NR3C1 (0.80) | NR3C1PGRCYP3A4CYP2C9 | |
| SCHEMBL4738893 | 0.72 | SMO (0.47) | NR3C1SMO | |
| SCHEMBL4124674 | 0.66 | NR3C1 (1.00) | NR3C1PGRCYP3A4CYP2C9 | |
| SCHEMBL4120136 | 0.64 | NR3C1 (1.00) | NR3C1PGRCYP3A4CYP2C9 | |
| SCHEMBL4108810 | 0.64 | NR3C1 (1.00) | NR3C1PGRCYP3A4CYP2C9 | |
| SCHEMBL4736970 | 0.62 | NR3C1 (0.53) | NR3C1PGR | |
| SCHEMBL4853828 | 0.61 | SMO (0.59) | NR3C1SMOPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008079073-A1 | INDAZOLYL SULPHONAMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | ASTRAZENECA AB (SE) | 2008-07-03 | — | — | WO | claimed |