Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 15/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4853828 | 0.84 | SMO (0.59) | SMOHTR2AHTR2C | |
| SCHEMBL4738893 | 0.76 | SMO (0.47) | SMO | |
| SCHEMBL4736966 | 0.75 | NR3C1 (0.58) | — | |
| SCHEMBL4114416 | 0.75 | NR3C1 (0.44) | CYP11B2CYP11B1 | |
| SCHEMBL4784906 | 0.75 | NR3C1 (0.49) | SMO | |
| SCHEMBL10770756 | 0.69 | SLC6A2 (0.41) | — | |
| SCHEMBL17892204 | 0.68 | SMO (0.50) | SMOCYP11B2HTR2A | |
| Hydrochloric Acid SCHEMBL10771402 | 0.68 | SLC6A2 (0.40) | — | |
| SCHEMBL20180252 | 0.66 | SMO (0.59) | SMOCYP11B2 | |
| SCHEMBL29741071 | 0.65 | CYP11B2 (0.55) | CYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008079073-A1 | INDAZOLYL SULPHONAMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | ASTRAZENECA AB (SE) | 2008-07-03 | — | — | WO | disclosed |