Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 5/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL924443 | 0.95 | HSD17B10 (0.41) | AURKAAURKBINCENPPARP1HSD17B10 | |
| SCHEMBL28271187 | 0.78 | ALDH1A1 (0.39) | AURKAAURKBINCENPPARP1HSD17B10 | |
| SCHEMBL21383788 | 0.78 | SMN1; SMN2 (0.45) | ALDH1A1HPGDTP53MAPTL3MBTL1 | |
| SCHEMBL9234686 | 0.77 | MAPT (0.46) | AURKAAURKBINCENPGFERDAO | |
| SCHEMBL1439000 | 0.76 | GFER (0.44) | HSD17B10GFERAPOBEC3AAPOBEC3GALDH1A1 | |
| SCHEMBL28807259 | 0.75 | MAPT (0.49) | AURKAAURKBINCENPGFERDAO | |
| SCHEMBL30088186 | 0.75 | HTR6 (0.39) | PARP1HSD17B10GFERAPOBEC3AAPOBEC3G | |
| SCHEMBL21805200 | 0.75 | HTR6 (0.39) | PARP1HSD17B10GFERAPOBEC3AAPOBEC3G | |
| SCHEMBL10751956 | 0.74 | ALDH1A1 (0.42) | AURKAAURKBINCENPHSD17B10ALDH1A1 | |
| SCHEMBL28834312 | 0.74 | KEAP1 (0.53) | HSD17B10GFERAPOBEC3AAPOBEC3GALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008074450-A2 | NON-PEPTIDIC RENIN INHIBITORS NITRODERIVATIVES | NICOX S.A. (FR) | 2008-06-26 | — | — | WO | claimed |
| WO-2008074450-A2 | NON-PEPTIDIC RENIN INHIBITORS NITRODERIVATIVES | NICOX S.A. (FR) | 2008-06-26 | — | — | WO | disclosed |