Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 9/20 | 0.47 |
| ▸ | DRD4 | P21917 | 7/20 | 0.47 |
| ▸ | HTR2A | P28223 | 7/20 | 0.47 |
| ▸ | DRD3 | P35462 | 7/20 | 0.47 |
| ▸ | HTR7 | P34969 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 7/20 | 0.43 |
| ▸ | DRD1 | P21728 | 2/20 | 0.43 |
| ▸ | DRD5 | P21918 | 2/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 3/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4735555 | 0.92 | TSHR (0.53) | TSHRGAADRD4DRD3KDM4E | |
| SCHEMBL4736483 | 0.91 | TSHR (0.47) | TSHRGAAHTR1ADRD4HTR2A | |
| SCHEMBL4737659 | 0.90 | KDM4E (0.47) | TSHRHTR1ADRD4HTR2ADRD3 | |
| SCHEMBL4737126 | 0.89 | TSHR (0.48) | TSHRGAAHTR1ADRD4HTR2A | |
| SCHEMBL4739086 | 0.88 | TSHR (0.52) | TSHRGAAHTR1ADRD4HTR2A | |
| SCHEMBL4738239 | 0.88 | TSHR (0.49) | TSHRGAAHTR1ADRD4HTR2A | |
| SCHEMBL4736584 | 0.86 | TSHR (0.51) | TSHRGAAHTR1ADRD4HTR2A | |
| SCHEMBL4738789 | 0.86 | OPRM1 (0.49) | TSHRHTR1ADRD4HTR2ADRD3 | |
| SCHEMBL4733936 | 0.86 | OPRM1 (0.49) | TSHRHTR1ADRD4HTR2ADRD3 | |
| SCHEMBL4735150 | 0.86 | TSHR (0.51) | TSHRGAAKDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |