Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | SMO | Q99835 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4785409 | 0.92 | TSHR (0.52) | TSHRGAAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL4737126 | 0.90 | TSHR (0.48) | TSHRGAAOPRM1OPRK1ALDH1A1 | |
| SCHEMBL4733666 | 0.90 | OPRM1 (0.49) | TSHROPRM1OPRK1ALDH1A1KDM4E | |
| SCHEMBL4739086 | 0.89 | TSHR (0.52) | TSHRGAAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL4736483 | 0.89 | TSHR (0.47) | TSHRGAAOPRM1OPRK1ALDH1A1 | |
| SCHEMBL4736584 | 0.88 | TSHR (0.51) | TSHRGAAOPRM1OPRK1ALDH1A1 | |
| SCHEMBL4738239 | 0.88 | TSHR (0.49) | TSHRGAAOPRM1OPRK1ALDH1A1 | |
| SCHEMBL4735150 | 0.87 | TSHR (0.51) | TSHRGAAOPRM1OPRK1ALDH1A1 | |
| SCHEMBL4736577 | 0.86 | TSHR (0.49) | TSHRGAAALDH1A1KDM4EMAPT | |
| SCHEMBL4784137 | 0.86 | PDK1 (0.50) | TSHRGAAALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |