Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.41 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | ME2 | P23368 | 1/20 | 0.39 |
| ▸ | ME1 | P48163 | 1/20 | 0.39 |
| ▸ | ME3 | Q16798 | 1/20 | 0.39 |
| ▸ | EP300 | Q09472 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4736729 | 0.96 | TSHR (0.46) | TSHRGAAHTTCXCR2MAPK14 | |
| SCHEMBL4737126 | 0.92 | TSHR (0.48) | TSHRGAAHTTCXCR2MAPK14 | |
| SCHEMBL4736584 | 0.91 | TSHR (0.51) | TSHRGAAHTTCXCR2MAPK14 | |
| SCHEMBL4739086 | 0.91 | TSHR (0.52) | TSHRGAAHTTCXCR2MAPK14 | |
| SCHEMBL4735150 | 0.91 | TSHR (0.51) | TSHRGAAHTTCXCR2MAPK14 | |
| SCHEMBL3830332 | 0.91 | MEN1 (0.45) | TSHRGAACXCR2MAPK14OPRM1 | |
| SCHEMBL4736483 | 0.90 | TSHR (0.47) | TSHRGAACXCR2MAPK14KCNH2 | |
| SCHEMBL4736473 | 0.90 | OPRM1 (0.41) | TSHRCXCR2MAPK14OPRM1KDM4E | |
| SCHEMBL4735615 | 0.90 | MAPK14 (0.45) | TSHRCXCR2MAPK14OPRM1OPRD1 | |
| SCHEMBL4784137 | 0.89 | PDK1 (0.50) | TSHRGAAHTTCXCR2MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |