Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.48 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.48 |
| ▸ | AAK1 | Q2M2I8 | 6/20 | 0.45 |
| ▸ | KIT | P10721 | 2/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | SGK1 | O00141 | 2/20 | 0.41 |
| ▸ | TNIK | Q9UKE5 | 3/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4200987 | 0.80 | MAPK8 (0.60) | PRMT5WDR77AAK1KITLRRK2 | |
| SCHEMBL21069142 | 0.79 | PRMT5 (0.54) | PRMT5WDR77AAK1KITLRRK2 | |
| SCHEMBL4747825 | 0.77 | PRMT5 (0.49) | PRMT5WDR77AAK1KITLRRK2 | |
| SCHEMBL4743347 | 0.76 | PRMT5 (0.56) | PRMT5WDR77AAK1KITLRRK2 | |
| SCHEMBL4745695 | 0.75 | DYRK1B (0.64) | PRMT5WDR77CLK1DYRK1ADYRK2 | |
| SCHEMBL4743697 | 0.75 | PRMT5 (0.53) | PRMT5WDR77AAK1KITCLK1 | |
| SCHEMBL4746507 | 0.74 | DYRK1A (0.56) | PRMT5WDR77AAK1LRRK2CLK1 | |
| SCHEMBL4743365 | 0.74 | DYRK1A (0.58) | PRMT5WDR77AAK1KITLRRK2 | |
| SCHEMBL4746489 | 0.72 | MAPK8 (0.51) | PRMT5WDR77AAK1KITLRRK2 | |
| SCHEMBL4743685 | 0.72 | PRMT5 (0.50) | PRMT5WDR77AAK1LRRK2DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | claimed |
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | disclosed |