Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | MPI | P34949 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10200865 | 0.79 | PRMT5 (0.35) | PRMT5WDR77ELANEGAA | |
| SCHEMBL27192249 | 0.76 | PRMT5 (0.36) | PRMT5WDR77ELANE | |
| SCHEMBL27192312 | 0.76 | PRMT5 (0.34) | PRMT5WDR77ELANE | |
| SCHEMBL4783388 | 0.76 | PRMT5 (0.34) | PRMT5WDR77ELANE | |
| SCHEMBL31509787 | 0.76 | PRMT5 (0.36) | PRMT5WDR77ELANE | |
| SCHEMBL2045577 | 0.72 | ALDH1A1 (0.48) | ELANEMAPTKMT2AESR1MAPK10 | |
| SCHEMBL4781714 | 0.69 | ESR2 (0.49) | ELANEMAPTKMT2AESR1KDM4E | |
| Propane SCHEMBL28825828 | 0.68 | MTNR1A (0.47) | ELANEMAPTKMT2AESR1MAPK10 | |
| SCHEMBL9118476 | 0.68 | ESR2 (0.42) | ELANEMAPTKMT2AESR1MAPK10 | |
| SCHEMBL10833455 | 0.68 | KCNA3 (0.40) | ELANEMAPTKMT2AESR1MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008057402-A2 | N-ARYL-ISOXAZOLOPYRIMIDIN-4-AMINES AND RELATED COMPOUNDS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2008-05-15 | — | — | WO | disclosed |