Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | PAM | P19021 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.45 |
| ▸ | CAMK2A | Q9UQM7 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.43 |
| ▸ | UGT1A9 | O60656 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.43 |
| ▸ | ALB | P02768 | 1/20 | 0.43 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1425327 | 0.85 | PTGS2 (0.54) | TTRCAMK2APTGS2AKR1B10UGT1A9 | |
| SCHEMBL4169475 | 0.79 | KMT2A (0.38) | TTRKMT2AUSP2LMNACYP2C9 | |
| SCHEMBL9446699 | 0.78 | PAM (0.67) | TTRKMT2AUSP2LMNACYP2C9 | |
| Aceclofenac SCHEMBL25734 | 0.75 | TTR (1.00) | TTRKMT2AUSP2LMNACYP2C9 | |
| Aceclofenac SCHEMBL29364020 | 0.75 | TTR (1.00) | TTRKMT2AUSP2LMNACYP2C9 | |
| SCHEMBL23691079 | 0.75 | TTR (0.76) | TTRKMT2AUSP2LMNACYP2C9 | |
| Aceclofenac SCHEMBL16697727 | 0.74 | TTR (0.97) | TTRKMT2AUSP2LMNACYP2C9 | |
| Aceclofenac SCHEMBL2905138 | 0.74 | TTR (0.97) | TTRKMT2AUSP2LMNACYP2C9 | |
| Aceclofenac SCHEMBL28443210 | 0.74 | TTR (0.97) | TTRKMT2AUSP2LMNACYP2C9 | |
| Aceclofenac SCHEMBL27918955 | 0.74 | TTR (0.97) | TTRKMT2AUSP2LMNACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539729-A4 | NITROSATED NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE | NITROMED INC (US) | 2008-02-20 | — | — | EP | disclosed |
| EP-1539729-A2 | NITROSATED NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE | Nitromed, Inc. (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004004648-A2 | NITROSATED NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE | NITROMED, INC. (US) | 2004-01-15 | — | — | WO | disclosed |