Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.35 |
| ▸ | REN | P00797 | 8/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.33 |
| ▸ | SYK | P43405 | 2/20 | 0.33 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4786330 | 1.00 | GPR119 (0.35) | GPR119RENGABRA5SYKFFAR2 | |
| SCHEMBL4785830 | 0.90 | REN (0.36) | GPR119RENPOLB | |
| SCHEMBL12750489 | 0.80 | REN (0.36) | GPR119RENMMP13 | |
| SCHEMBL1752424 | 0.77 | NPBWR1 (0.38) | GPR119 | |
| SCHEMBL1751573 | 0.77 | NPBWR1 (0.38) | GPR119 | |
| SCHEMBL1752248 | 0.76 | GPR119 (0.38) | GPR119RENGABRA5PIK3CDMMP13 | |
| SCHEMBL4687040 | 0.75 | REN (0.39) | RENGABRA5 | |
| SCHEMBL1751956 | 0.73 | PIK3CD (0.41) | RENSYKPIK3CD | |
| SCHEMBL1751190 | 0.73 | PIK3CD (0.41) | RENSYKPIK3CD | |
| SCHEMBL1751769 | 0.72 | ESR2 (0.39) | GPR119GABRA5PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981847-A1 | SECONDARY AMINES AS RENIN INHIBITORS | Actelion Pharmaceuticals Ltd. (CH) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007088514-A1 | SECONDARY AMINES AS RENIN INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2007-08-09 | — | — | WO | disclosed |