SCHEMBL4786345

SCHEMBL4786345

CNCCC(O)c1ccc(OC)c(OC)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARG P37231 1/20 0.51
PPARD Q03181 1/20 0.51
PPARA Q07869 1/20 0.51
POLB P06746 1/20 0.50
ATM Q13315 1/20 0.50
CYP3A4 P08684 3/20 0.47
TSHR P16473 3/20 0.47
PDE4D Q08499 3/20 0.47
PDE4A P27815 2/20 0.47
PDE4B Q07343 2/20 0.47
PDE4C Q08493 2/20 0.47
SLC6A4 P31645 2/20 0.47
SLC6A3 Q01959 2/20 0.47
SLC6A2 P23975 2/20 0.47
MEN1 O00255 1/20 0.47
CYP1A2 P05177 1/20 0.47
CYP2D6 P10635 1/20 0.47
CYP2C19 P33261 1/20 0.47
KMT2A Q03164 1/20 0.47
NFKB1 P19838 3/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19407169 1.00 PPARG (0.51) PPARGPPARDPPARAPOLBATM
SCHEMBL10335590 0.86 PPARG (0.61) PPARGPPARDPPARACYP3A4TSHR
SCHEMBL3652526 0.83 HIF1A (0.58) PPARGPPARDPPARACYP3A4TSHR
SCHEMBL29511863 0.83 HIF1A (0.58) PPARGPPARDPPARACYP3A4TSHR
SCHEMBL6581628 0.83 NFKB1 (0.57) PPARGPPARDPPARAATMCYP3A4
Hydrochloric Acid SCHEMBL3656870 0.82 ADRB2 (0.59) PPARGPPARDPPARACYP3A4TSHR
SCHEMBL6584190 0.82 ACHE (0.47) PPARGPPARDPPARACYP3A4TSHR
SCHEMBL6491466 0.81 PPARG (0.60) PPARGPPARDPPARACYP3A4TSHR
SCHEMBL5492854 0.81 PDE4D (0.64) PPARGPPARDPPARACYP3A4TSHR
SCHEMBL7326986 0.80 PPARG (0.54) PPARGPPARDPPARACYP3A4TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008081477-A1 3-ARYLOXY 3-SUBSTITUTED PROPANAMINES NATCO PHARMA LIMITED (IN) 2008-07-10 WO disclosed