Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 9/20 | 0.54 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | USP5 | P45974 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782830 | 0.89 | HSD11B1 (0.62) | HSD11B1LMNATSHRMAPK1ALDH1A1 | |
| SCHEMBL4786375 | 0.89 | HSD11B1 (0.62) | HSD11B1LMNATSHRMAPK1ALDH1A1 | |
| SCHEMBL4740379 | 0.86 | HSD11B1 (0.56) | HSD11B1LMNATSHRMAPK1ALDH1A1 | |
| SCHEMBL4736702 | 0.86 | HSD11B1 (0.58) | HSD11B1LMNATSHRMAPK1ALDH1A1 | |
| SCHEMBL4738968 | 0.85 | HSD11B1 (0.58) | HSD11B1TSHRALDH1A1CYP2C19AKR1C3 | |
| SCHEMBL4740136 | 0.85 | USP5 (0.53) | MMP2MMP13USP5LMNATSHR | |
| SCHEMBL4739901 | 0.84 | HSD11B1 (0.61) | HSD11B1LMNATSHRMAPK1ALDH1A1 | |
| SCHEMBL4736686 | 0.83 | HDAC3 (0.50) | HSD11B1TSHRNPSR1HDAC3HDAC4 | |
| SCHEMBL4912062 | 0.82 | HSD11B1 (0.54) | HSD11B1LMNAALDH1A1NPSR1HDAC3 | |
| SCHEMBL4736614 | 0.82 | HSD11B1 (0.66) | HSD11B1LMNATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008087654-A2 | PIPERIDINES AS INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | CADILA HEALTHCARE LIMITED (IN) | 2008-07-24 | — | — | WO | claimed |
| WO-2008087654-A2 | PIPERIDINES AS INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | CADILA HEALTHCARE LIMITED (IN) | 2008-07-24 | — | — | WO | disclosed |