Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.56 |
| ▸ | DRD3 | P35462 | 4/20 | 0.56 |
| ▸ | HTR1D | P28221 | 3/20 | 0.56 |
| ▸ | MTNR1A | P48039 | 7/20 | 0.54 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TAOK3 | Q9H2K8 | 4/20 | 0.42 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4788623 | 0.88 | DRD2 (0.56) | DRD2DRD3HTR1DMTNR1AMTNR1B | |
| SCHEMBL4789096 | 0.85 | DRD2 (0.54) | DRD2DRD3HTR1DMTNR1AMTNR1B | |
| SCHEMBL4750932 | 0.84 | SCN9A (0.50) | KCNH2 | |
| SCHEMBL4786804 | 0.81 | MTNR1A (0.55) | DRD2DRD3HTR1DMTNR1AMTNR1B | |
| SCHEMBL7031626 | 0.78 | KCNH2 (0.56) | DRD2DRD3HTR1DMTNR1AMTNR1B | |
| SCHEMBL4788640 | 0.78 | KCNH2 (0.56) | DRD2DRD3HTR1DMTNR1AMTNR1B | |
| SCHEMBL7031622 | 0.78 | KCNH2 (0.56) | DRD2DRD3HTR1DMTNR1AMTNR1B | |
| SCHEMBL4786534 | 0.77 | MTNR1A (0.54) | DRD2DRD3HTR1DMTNR1AMTNR1B | |
| SCHEMBL841202 | 0.76 | SCN9A (0.55) | DRD2DRD3HTR1DMTNR1AMTNR1B | |
| SCHEMBL9406454 | 0.75 | MTNR1A (0.69) | DRD2DRD3HTR1DMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130319-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR N-CHROMANE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | claimed |
| WO-2008130319-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR N-CHROMANE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |