Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 7/20 | 0.55 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.55 |
| ▸ | DRD2 | P14416 | 4/20 | 0.52 |
| ▸ | DRD3 | P35462 | 3/20 | 0.52 |
| ▸ | HTR1D | P28221 | 2/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4788640 | 0.85 | KCNH2 (0.56) | MTNR1AMTNR1BDRD2DRD3HTR1D | |
| SCHEMBL7031622 | 0.85 | KCNH2 (0.56) | MTNR1AMTNR1BDRD2DRD3HTR1D | |
| SCHEMBL7031626 | 0.85 | KCNH2 (0.56) | MTNR1AMTNR1BDRD2DRD3HTR1D | |
| SCHEMBL4788553 | 0.83 | KCNH2 (0.55) | MTNR1AMTNR1BKCNH2SCN9AMAPT | |
| SCHEMBL4788572 | 0.82 | MTNR1A (0.51) | MTNR1AMTNR1BKCNH2SCN5ASCN9A | |
| SCHEMBL4786508 | 0.81 | DRD2 (0.56) | MTNR1AMTNR1BDRD2DRD3HTR1D | |
| SCHEMBL4788623 | 0.81 | DRD2 (0.56) | MTNR1AMTNR1BDRD2DRD3HTR1D | |
| SCHEMBL4789096 | 0.79 | DRD2 (0.54) | MTNR1AMTNR1BDRD2DRD3HTR1D | |
| SCHEMBL839320 | 0.78 | MTNR1A (0.46) | MTNR1AMTNR1BDRD2DRD3HTR1D | |
| SCHEMBL3807675 | 0.78 | MTNR1A (0.46) | MTNR1AMTNR1BDRD2DRD3HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130319-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR N-CHROMANE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | claimed |
| WO-2008130319-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR N-CHROMANE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |