Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | DRD5 | P21918 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4786874 | 0.89 | DRD2 (0.52) | DRD2DRD3ADRA1ACHRM2CHRM1 | |
| SCHEMBL4746896 | 0.79 | PDGFRB (0.39) | DRD2PDGFRBFGFR1KDRMEN1 | |
| SCHEMBL4788734 | 0.79 | DRD2 (0.49) | DRD2DRD3CHRM2CHRM1CHRM3 | |
| Ammonia Solution, Strong SCHEMBL4750926 | 0.78 | PDGFRB (0.38) | DRD2PDGFRBFGFR1KDRMEN1 | |
| SCHEMBL14559957 | 0.75 | DRD2 (0.55) | DRD2DRD3PDGFRBFGFR1KDR | |
| SCHEMBL8076233 | 0.74 | DRD2 (0.79) | DRD2DRD3ADRA1ACHRM2CHRM1 | |
| SCHEMBL4210081 | 0.74 | DRD2 (0.79) | DRD2DRD3ADRA1ACHRM2CHRM1 | |
| SCHEMBL266921 | 0.74 | DRD2 (0.79) | DRD2DRD3ADRA1ACHRM2CHRM1 | |
| SCHEMBL4750927 | 0.74 | PDGFRB (0.41) | PDGFRBFGFR1KDRMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL7028613 | 0.73 | DRD2 (0.77) | DRD2DRD3ADRA1ACHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130319-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR N-CHROMANE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | claimed |
| WO-2008130319-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR N-CHROMANE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |