Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | GAA | P10253 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.67 |
| ▸ | HTR2A | P28223 | 3/20 | 0.63 |
| ▸ | HTR1A | P08908 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.62 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.60 |
| ▸ | CDK4 | P11802 | 1/20 | 0.58 |
| ▸ | CCND1 | P24385 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
| ▸ | HTR7 | P34969 | 1/20 | 0.58 |
| ▸ | HTR6 | P50406 | 1/20 | 0.58 |
| ▸ | MC5R | P33032 | 1/20 | 0.57 |
| ▸ | MC3R | P41968 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6599683 | 0.88 | HTR2A (0.71) | HRH3KMT2AMEN1MAPTHTR2A | |
| Hydrochloric Acid SCHEMBL11602872 | 0.86 | HTR2A (0.70) | HRH3KMT2AMEN1MAPTHTR2A | |
| SCHEMBL8263255 | 0.85 | HTR2A (0.65) | HRH3KMT2AMEN1HTR2AHTR1A | |
| SCHEMBL28413707 | 0.85 | HRH3 (0.63) | HRH3KMT2AMEN1HTR2AHTR1A | |
| SCHEMBL13119267 | 0.85 | HRH3 (0.59) | HRH3KMT2AMEN1GAAMAPT | |
| SCHEMBL14494802 | 0.85 | HRH3 (0.62) | HRH3KMT2AMEN1HTR2AHTR1A | |
| SCHEMBL7006163 | 0.85 | DRD2 (0.73) | HRH3KMT2AMEN1MAPTHTR2A | |
| SCHEMBL19778568 | 0.83 | HRH3 (0.67) | HRH3KMT2AMEN1HTR2AHTR1A | |
| SCHEMBL7011744 | 0.83 | GOT1 (0.70) | HRH3KMT2AMEN1MAPTHTR2A | |
| SCHEMBL8264766 | 0.82 | CDK2 (0.61) | HRH3KMT2AMEN1MAPTHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393801-B1 | INHIBITORS OF THE INTERACTION BETWEEN MDM2 AND P53 | JANSSEN PHARMACEUTICA NV (BE) | 2017-07-12 | — | — | EP | disclosed |
| US-8921376-B2 | Pyrrolopyridines useful as inhibitors of protein kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-12-30 | — | — | US | disclosed |
| US-8921376-B2 | Pyrrolopyridines useful as inhibitors of protein kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-12-30 | — | — | US | disclosed |
| US-8404683-B2 | Inhibitors of the interaction between MDM2 and P53 | JANSSEN PHARMACEUTICAL N.V. (BE) | 2013-03-26 | — | — | US | disclosed |
| EP-2354139-A1 | Pyrrolopyridines useful as inhibitors of protein kinase | Vertex Pharmaceuticals Incorporated (US) | 2011-08-10 | — | — | EP | disclosed |
| EP-2354140-A1 | Pyrrolopyridines useful as inhibitors of protein kinase | Vertex Pharmaceuticals Incorporated (US) | 2011-08-10 | — | — | EP | disclosed |
| US-20070135466-A1 | Pyrrolopyridines useful as inhibitors of protein kinase | VERTEX PHARMACEUTICALS INCORPORATED | 2007-06-14 | — | — | US | disclosed |
| US-20070135466-A1 | Pyrrolopyridines useful as inhibitors of protein kinase | VERTEX PHARMACEUTICALS INCORPORATED | 2007-06-14 | — | — | US | disclosed |
| WO-2006032631-A1 | INHIBITORS OF THE INTERACTION BETWEEN MDM2 AND P53 | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-03-30 | — | — | WO | disclosed |
| EP-0923581-B1 | 4-SUBSTITUTED BETA-CARBOLINES AS IMMUNOMODULATORS | BOEHRINGER INGELHEIM PHARMA (US) | 2003-05-21 | — | — | EP | disclosed |
| US-6093723-A | AN IMMUNOMODULATOR FOR TREATING AND PREVENTING IMMUNE DISORDERS, INCLUDING AUTOIMMUNE DISEASE, INFLAMMATORY DISEASE, ORGAN TRANSPLANT REJECTION AND OTHER DISORDERS ASSOCIATED WITH IL-2 MEDIATED IMMUNE RESPONSE | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2000-07-25 | — | — | US | disclosed |
| EP-0677042-B1 | SELECTIVE LIGANDS OF 5HT1D-5HT1B RECEPTORS DERIVED FROM INDOLE-PIPERAZINE USEFUL AS MEDICAMENTS | PF MEDICAMENT (FR) | 1998-07-22 | — | — | EP | disclosed |
| EP-0677042-A1 | SELECTIVE LIGANDS OF RECEPTORS 5-HT 1D?-5HT 1B? DERIVED FROM INDOLE-PIPERAZINE USEFUL AS MEDICAMENTS | PIERRE FABRE MEDICAMENT (FR) | 1995-10-18 | — | — | EP | disclosed |
| WO-1994015916-A1 | SELECTIVE LIGANDS OF RECEPTORS 5-HT1D-5HT1B DERIVED FROM INDOLE-PIPERAZINE USEFUL AS MEDICAMENTS | PIERRE FABRE MEDICAMENT (FR) | 1994-07-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135466-A1 | Pyrrolopyridines useful as inhibitors of protein kinase | JAK2, JAK1, JAK3 | HRH3 3011/4885KMT2A 2135/4885MEN1 2060/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.