SCHEMBL4787337

SCHEMBL4787337

CN1CCN(c2cccc3c2C=Nc2ccccc2S3)CC1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 5/20 0.44
DRD3 P35462 4/20 0.44
ADRA2C P18825 2/20 0.44
LMNA P02545 2/20 0.44
CHRM1 P11229 2/20 0.44
CHRM2 P08172 1/20 0.44
HTR1A P08908 1/20 0.44
ADRA2A P08913 1/20 0.44
ADRA2B P18089 1/20 0.44
CHRM3 P20309 1/20 0.44
DRD1 P21728 1/20 0.44
SLC6A2 P23975 1/20 0.44
HTR2A P28223 1/20 0.44
HTR2C P28335 1/20 0.44
SLC6A4 P31645 1/20 0.44
ADRA1A P35348 1/20 0.44
HRH1 P35367 1/20 0.44
OPRM1 P35372 1/20 0.44
OPRD1 P41143 1/20 0.44
HTR2B P41595 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3960510 0.85 TRPA1 (0.39) DRD2DRD3ADRA2CLMNACHRM1
SCHEMBL1568098 0.84 DRD2 (0.51) DRD2DRD3LMNAHTR1AHTR2A
SCHEMBL5809604 0.84 DRD2 (0.46) DRD2DRD3ADRA2CLMNACHRM1
Hydrochloric Acid SCHEMBL1773502 0.83 DRD2 (0.50) DRD2LMNAHTR1AHTR2AHTR3A
Hydrochloric Acid SCHEMBL4234715 0.83 DRD2 (0.50) DRD2LMNAHTR1AHTR2AHTR3A
SCHEMBL905217 0.78 DRD2 (0.60) DRD2DRD3ADRA2CLMNACHRM1
SCHEMBL3685628 0.78 HRH4 (0.51) DRD2DRD3ADRA2CLMNACHRM1
Hydrochloric Acid SCHEMBL5606159 0.77 HRH4 (0.50) DRD2DRD3ADRA2CLMNACHRM1
SCHEMBL5563082 0.76 HTR2A (0.46) DRD2DRD3ADRA2CLMNACHRM1
SCHEMBL5329365 0.76 DRD2 (0.46) DRD2DRD3ADRA2CLMNACHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009002507-A1 COMPOSITIONS AND METHODS FOR TREATING MEDICAL CONDITIONS COMBINATORX, INCORPORATED (US) 2008-12-31 WO disclosed
WO-2008085927-A2 METHODS, COMPOSITIONS, AND KITS FOR THE TREATMENT OF PAIN COMBINATORX, INCORPORATED (US) 2008-07-17 WO disclosed
EP-1691744-A4 METHODS AND REAGENTS FOR THE TREATMENT OF INFLAMMATORY DISORDERS COMBINATORX INC (US) 2007-12-26 EP disclosed
EP-1691744-A2 METHODS AND REAGENTS FOR THE TREATMENT OF INFLAMMATORY DISORDERS CombinatoRx, Incorporated (US) 2006-08-23 EP disclosed
WO-2005048927-A2 METHODS AND REAGENTS FOR THE TREATMENT OF INFLAMMATORY DISORDERS COMBINATORX, INCORPORATED (US) 2005-06-02 WO disclosed