Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 12/20 | 0.53 |
| ▸ | RAF1 | P04049 | 4/20 | 0.51 |
| ▸ | ARAF | P10398 | 3/20 | 0.51 |
| ▸ | CDK8 | P49336 | 4/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4788095 | 0.91 | BRAF (0.63) | BRAFRAF1ARAFMAPK14BTK | |
| SCHEMBL4788852 | 0.91 | BRAF (0.43) | BRAFRAF1ARAFCDK8MAPK14 | |
| SCHEMBL4788641 | 0.86 | LCK (0.49) | BRAFRAF1ARAFCDK8MAPK14 | |
| SCHEMBL4788889 | 0.85 | BMX (0.53) | BRAFRAF1MAPK14BTKKDR | |
| SCHEMBL4789707 | 0.84 | BRAF (0.47) | BRAFBTKJAK3 | |
| SCHEMBL4789920 | 0.84 | KDR (0.44) | BRAFRAF1MAPK14BTKKDR | |
| SCHEMBL4788647 | 0.83 | LCK (0.46) | BRAFRAF1ARAFMAPK14KDR | |
| SCHEMBL4788870 | 0.82 | KMT2A (0.60) | BRAFRAF1MAPK14 | |
| SCHEMBL4789713 | 0.82 | BMX (0.41) | BRAFMAPK14JAK3 | |
| SCHEMBL4788857 | 0.82 | BRAF (0.52) | BRAFRAF1ARAFMAPK14KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | claimed |
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |