Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.44 |
| ▸ | BMX | P51813 | 3/20 | 0.43 |
| ▸ | ABL1 | P00519 | 3/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.43 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 2/20 | 0.40 |
| ▸ | LCK | P06239 | 3/20 | 0.40 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.40 |
| ▸ | XPO1 | O14980 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.39 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4788889 | 0.90 | BMX (0.53) | KDRBMXABL1MAPK14SRC | |
| SCHEMBL4789921 | 0.89 | KDR (0.48) | KDRBMXABL1MAPK14SRC | |
| SCHEMBL4788852 | 0.86 | BRAF (0.43) | KDRBMXABL1MAPK14SRC | |
| SCHEMBL4788930 | 0.86 | MAPK14 (0.53) | ABL1MAPK14CSF1RRAF1BTK | |
| SCHEMBL4788092 | 0.84 | BRAF (0.53) | KDRMAPK14RAF1LCKBTK | |
| SCHEMBL4788673 | 0.84 | MAP3K7 (0.45) | KDRMAPK14SRCDDR1CSF1R | |
| SCHEMBL4788891 | 0.82 | CSF1R (0.61) | KDRBMXABL1MAPK14SRC | |
| SCHEMBL4788641 | 0.82 | LCK (0.49) | KDRBMXABL1MAPK14SRC | |
| SCHEMBL4789713 | 0.82 | BMX (0.41) | BMXABL1MAPK14SRCDDR1 | |
| SCHEMBL4790218 | 0.81 | BMX (0.49) | KDRBMXABL1MAPK14SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | claimed |
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |