Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 15/20 | 0.63 |
| ▸ | RAF1 | P04049 | 5/20 | 0.59 |
| ▸ | ARAF | P10398 | 4/20 | 0.59 |
| ▸ | KDR | P35968 | 3/20 | 0.50 |
| ▸ | BTK | Q06187 | 2/20 | 0.49 |
| ▸ | LCK | P06239 | 2/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.47 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.47 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4788857 | 0.91 | BRAF (0.52) | BRAFRAF1ARAFKDRLCK | |
| SCHEMBL4788092 | 0.91 | BRAF (0.53) | BRAFRAF1ARAFKDRBTK | |
| SCHEMBL4788891 | 0.85 | CSF1R (0.61) | BRAFRAF1KDRBTKLCK | |
| SCHEMBL4788647 | 0.84 | LCK (0.46) | BRAFRAF1ARAFKDRLCK | |
| SCHEMBL4789710 | 0.84 | BRAF (0.52) | BRAFBTKMAPK14DDR1CSF1R | |
| SCHEMBL4788872 | 0.83 | DDR1 (0.70) | BRAFRAF1BTKMAPK14DDR1 | |
| SCHEMBL4789921 | 0.83 | KDR (0.48) | BRAFRAF1KDRLCKMAPK14 | |
| SCHEMBL4789714 | 0.82 | BRAF (0.48) | BRAFRAF1KDRMAPK14DDR1 | |
| SCHEMBL4788852 | 0.82 | BRAF (0.43) | BRAFRAF1ARAFKDRLCK | |
| SCHEMBL4788672 | 0.81 | LMNA (0.50) | BRAFRAF1KDRMAPK14DDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | claimed |
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |