Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.47 |
| ▸ | JAK1 | P23458 | 10/20 | 0.46 |
| ▸ | JAK2 | O60674 | 8/20 | 0.46 |
| ▸ | TYK2 | P29597 | 8/20 | 0.46 |
| ▸ | JAK3 | P52333 | 7/20 | 0.46 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.43 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4789713 | 0.91 | BMX (0.41) | BRAFJAK1JAK2TYK2JAK3 | |
| SCHEMBL4789710 | 0.89 | BRAF (0.52) | BRAFMEN1KMT2ARXFP1BTK | |
| SCHEMBL4789786 | 0.89 | EGFR (0.43) | BRAFJAK1JAK2TYK2JAK3 | |
| SCHEMBL4789712 | 0.88 | BMX (0.49) | JAK1JAK2TYK2JAK3MAPT | |
| SCHEMBL4788889 | 0.87 | BMX (0.53) | BRAFRXFP1MAPTBTKABL1 | |
| SCHEMBL4788092 | 0.84 | BRAF (0.53) | BRAFJAK3BTK | |
| SCHEMBL4788852 | 0.83 | BRAF (0.43) | BRAFABL1 | |
| SCHEMBL4789714 | 0.82 | BRAF (0.48) | BRAFKMT2ARXFP1MAPTABL1 | |
| SCHEMBL4788641 | 0.82 | LCK (0.49) | BRAFJAK3KMT2AABL1 | |
| SCHEMBL14027871 | 0.80 | JAK1 (0.42) | BRAFJAK1JAK2TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | claimed |
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |