Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 4/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 2/20 | 0.31 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.31 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.31 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1244741 | 0.73 | AXL (0.43) | KDRABL1AXLCDK2CHEK1 | |
| SCHEMBL13990648 | 0.73 | AXL (0.43) | KDRABL1AXLCDK2CHEK1 | |
| SCHEMBL14565531 | 0.69 | GSK3B (0.43) | AXLCDK2GSK3B | |
| SCHEMBL5090716 | 0.66 | ALDH1A1 (0.47) | KMT2AKDM4E | |
| SCHEMBL5799845 | 0.65 | TLR8 (0.48) | KDRABL1AXLCDK2CHEK1 | |
| SCHEMBL3162758 | 0.65 | SMN1; SMN2 (0.56) | KDM4EHTTGSK3BMAP2K1CLK4 | |
| SCHEMBL30363736 | 0.63 | KDR (0.49) | KDRABL1AXLCDK2CHEK1 | |
| SCHEMBL13309475 | 0.63 | PRKAB2 (0.40) | KDRABL1AXLCDK2MEN1 | |
| SCHEMBL13305185 | 0.62 | GSK3B (0.67) | CDK2GSK3B | |
| SCHEMBL23728455 | 0.62 | HSD11B1 (0.40) | KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080300263-A1 | Pyrazolo [1,5-a] pyrimidine compounds and pharmaceutical compositions containing them | EIRX THERAPEUTICS PLC (IE) | 2008-12-04 | — | — | US | disclosed |
| EP-1922321-A1 | PYRAZOLOÝ1,5-A¨PYRIMIDINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Eirx Therapeutics Ltd (IE) | 2008-05-21 | — | — | EP | disclosed |
| WO-2007017678-A1 | PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | EIRX THERAPEUTICS LIMITED (IE) | 2007-02-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080300263-A1 | Pyrazolo [1,5-a] pyrimidine compounds and pharmaceutical compositions containing them | DPYD, TYMS, TYMP | KDR 2824/4885ABL1 1312/4885AXL 1536/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.