Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4789431 | 0.86 | SCN9A (0.60) | SMN1; SMN2ROCK1KCNH2SCN5ASCN9A | |
| SCHEMBL7031232 | 0.81 | MEN1 (0.55) | KCNH2SCN5ASCN9AMEN1KMT2A | |
| SCHEMBL7030282 | 0.81 | MEN1 (0.55) | KCNH2SCN5ASCN9AMEN1KMT2A | |
| SCHEMBL2079393 | 0.81 | SMN1; SMN2 (0.62) | SMN1; SMN2NPY5RROCK1CCR1KDM4E | |
| SCHEMBL4788895 | 0.81 | KCNH2 (0.49) | KCNH2SCN5ASCN9AMEN1KMT2A | |
| SCHEMBL6820338 | 0.79 | KCNH2 (0.55) | SMN1; SMN2KCNH2SCN5ASCN9AMEN1 | |
| SCHEMBL6820334 | 0.79 | KCNH2 (0.55) | SMN1; SMN2KCNH2SCN5ASCN9AMEN1 | |
| SCHEMBL7025761 | 0.79 | KCNH2 (0.55) | SMN1; SMN2KCNH2SCN5ASCN9AMEN1 | |
| SCHEMBL4789479 | 0.78 | LCK (0.46) | KCNH2SCN5ASCN9AKDM4EMEN1 | |
| SCHEMBL2079395 | 0.78 | LMNA (0.58) | SMN1; SMN2NPY5RROCK1CCR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130321-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR 5-HETEROCYCLYL-CHROMANE OR 8-HETEROCYCLYL-TETRAHYDRONAPHTALENE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | claimed |
| WO-2008130321-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR 5-HETEROCYCLYL-CHROMANE OR 8-HETEROCYCLYL-TETRAHYDRONAPHTALENE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |