Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.59 |
| ▸ | HTR2A | P28223 | 6/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 3/20 | 0.49 |
| ▸ | HTR2B | P41595 | 2/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | PRCP | P42785 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.41 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | PNMT | P11086 | 1/20 | 0.40 |
| ▸ | CD44 | P16070 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9252509 | 0.98 | ADRA2A (0.58) | ADRA2AADRA2BHTR2ASIGMAR1HTR2C | |
| SCHEMBL29140051 | 0.96 | ADRA2A (0.61) | ADRA2AADRA2BHTR2ASIGMAR1HTR2C | |
| SCHEMBL29028946 | 0.88 | ADRA2A (0.47) | ADRA2AADRA2BHTR2ASIGMAR1HTR2C | |
| SCHEMBL29140058 | 0.84 | ADRA2A (0.53) | ADRA2AADRA2BHTR2AHTR2CHTR2B | |
| SCHEMBL9063316 | 0.84 | ADRA2A (0.53) | ADRA2AADRA2BHTR2ASIGMAR1HTR2C | |
| SCHEMBL1956137 | 0.83 | SIGMAR1 (0.67) | ADRA2AADRA2BHTR2ASIGMAR1HTR2C | |
| Hydrochloric Acid SCHEMBL6797184 | 0.81 | HTR2C (0.68) | ADRA2AADRA2BHTR2ASIGMAR1HTR2C | |
| SCHEMBL8960083 | 0.79 | ADRA2A (0.61) | ADRA2AADRA2BHTR2AHTR2CHTR2B | |
| SCHEMBL8960144 | 0.79 | ADRA2A (0.61) | ADRA2AADRA2BHTR2AHTR2CHTR2B | |
| SCHEMBL4790041 | 0.79 | ADRA2A (0.56) | ADRA2AADRA2BHTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106518752-B | A kind of synthetic method of 5- phenyl -1,2,3,6- 5,6-tetrahydropyridine derivative | 山东理工大学 | 2019-07-26 | — | — | CN | claimed |
| CN-106518752-A | Synthesis method of 5-phenyl-1, 2, 3, 6-tetrahydropyridine derivative | 山东理工大学 | 2017-03-22 | — | — | CN | claimed |
| JP-6321899-A | — | — | None | — | — | JP | disclosed |
| CN-117185989-A | Synthesis method for preparing 5-aryl-1, 2,3, 6-tetrahydropyridine derivative by photo-induced palladium catalysis | 齐鲁医药学院 | 2023-12-08 | — | — | CN | disclosed |
| CN-117185989-A | Synthesis method for preparing 5-aryl-1, 2,3, 6-tetrahydropyridine derivative by photo-induced palladium catalysis | 齐鲁医药学院 | 2023-12-08 | — | — | CN | disclosed |
| WO-2020112941-A2 | SOLID STATE FORMS OF LUMATEPERONE SALTS AND PROCESSES FOR PREPARATION OF LUMATEPERONE AND SALTS THEREOF | TEVA CZECH INDUSTRIES S.R.O (CZ) | 2020-06-04 | — | — | WO | disclosed |
| CN-106518752-B | A kind of synthetic method of 5- phenyl -1,2,3,6- 5,6-tetrahydropyridine derivative | 山东理工大学 | 2019-07-26 | — | — | CN | disclosed |
| CN-106518752-B | A kind of synthetic method of 5- phenyl -1,2,3,6- 5,6-tetrahydropyridine derivative | 山东理工大学 | 2019-07-26 | — | — | CN | disclosed |
| CN-106518752-B | A kind of synthetic method of 5- phenyl -1,2,3,6- 5,6-tetrahydropyridine derivative | 山东理工大学 | 2019-07-26 | — | — | CN | disclosed |
| CN-106518752-A | Synthesis method of 5-phenyl-1, 2, 3, 6-tetrahydropyridine derivative | 山东理工大学 | 2017-03-22 | — | — | CN | disclosed |
| CN-106518752-A | Synthesis method of 5-phenyl-1, 2, 3, 6-tetrahydropyridine derivative | 山东理工大学 | 2017-03-22 | — | — | CN | disclosed |
| EP-0618194-A1 | 3-Phenyl-1,2,5,6-tetrahydropyridine and its use as a sedative | LABORATOIRE L. LAFON (FR) | 1994-10-05 | — | — | EP | disclosed |
| EP-0618194-A1 | 3-Phenyl-1,2,5,6-tetrahydropyridine and its use as a sedative | LABORATOIRE L. LAFON (FR) | 1994-10-05 | — | — | EP | disclosed |
| EP-0163238-B1 | SUBSTITUTED AND BRIDGED PYRIDINES USEFUL AS PHARMACEUTICAL AGENTS | MERCK & CO. INC. (US) | 1991-07-24 | — | — | EP | disclosed |
| EP-0192521-B1 | 3-PHENYL-TETRAHYDROPYRIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTICAL USE | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1988-12-14 | — | — | EP | disclosed |
| US-4663328-A | 3-Phenyl-tetrahydropyridine derivatives, and their use as sedative agents | LABORATOIRE L. LAFON (FR) | 1987-05-05 | — | — | US | disclosed |
| EP-0192521-A1 | 3-Phenyl-tetrahydropyridine derivatives, process for their preparation and their therapeutical use | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1986-08-27 | — | — | EP | disclosed |
| US-4077958-A | ANTIDEPRESSANTS | E. R. SQUIBB & SONS, INC. (US) | 1978-03-07 | — | — | US | disclosed |
| US-4007191-A | ANTIDEPRESSANT | E. R. SQUIBB & SONS, INC. (US) | 1977-02-08 | — | — | US | disclosed |
| US-3935227-A | ANTIDEPRESSANTS, ANTIANXIETY, ANTIINFLAMMATORY AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1976-01-27 | — | — | US | disclosed |