Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 10/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 7/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 7/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 4/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 2/20 | 0.36 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.36 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2215206 | 0.77 | ADRA1A (0.49) | ADRA2AADRA2BADRA2CADRA1AHTR1A | |
| SCHEMBL12437174 | 0.77 | ADRA1A (0.49) | ADRA2AADRA2BADRA2CADRA1AHTR1A | |
| SCHEMBL1718475 | 0.75 | LMNA (0.60) | ADRA2AADRA2BADRA2CADRA1AHTR1A | |
| SCHEMBL12442744 | 0.75 | LMNA (0.60) | ADRA2AADRA2BADRA2CADRA1AHTR1A | |
| SCHEMBL2216221 | 0.74 | ADRA2A (0.46) | ADRA2AADRA2BADRA2CADRA1AHTR7 | |
| Hydrochloric Acid SCHEMBL3501970 | 0.74 | LMNA (0.59) | ADRA2AADRA2BADRA2CADRA1AHTR1A | |
| Iodide SCHEMBL4667056 | 0.73 | ADRA2A (0.45) | ADRA2AADRA2BADRA2CADRA1AHTR7 | |
| SCHEMBL22147295 | 0.72 | HTR2A (0.46) | ADRA2AADRA2BADRA2CADRA1AHTR2A | |
| SCHEMBL9619466 | 0.71 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CADRA1AHTR7 | |
| SCHEMBL14067912 | 0.70 | NISCH (0.43) | ADRA2AADRA2BADRA2CADRA1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008123821-A1 | 4, 5-DIHYDRO-LH-IMIDAZOL-2-AMINE DERIVATIVES FOR USE IN THE TREATMENT OF RESPIRATORY, CARDIOVASCULAR, NEUROLOGICAL OR GASTROINTESTINAL DISORDERS | ALBIREO AB (SE) | 2008-10-16 | — | — | WO | claimed |
| WO-2008123821-A1 | 4, 5-DIHYDRO-LH-IMIDAZOL-2-AMINE DERIVATIVES FOR USE IN THE TREATMENT OF RESPIRATORY, CARDIOVASCULAR, NEUROLOGICAL OR GASTROINTESTINAL DISORDERS | ALBIREO AB (SE) | 2008-10-16 | — | — | WO | disclosed |