Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 5/20 | 0.58 |
| ▸ | ABL1 | P00519 | 2/20 | 0.56 |
| ▸ | BRAF | P15056 | 9/20 | 0.54 |
| ▸ | EGFR | P00533 | 5/20 | 0.54 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | LCK | P06239 | 3/20 | 0.49 |
| ▸ | SRC | P12931 | 2/20 | 0.49 |
| ▸ | INSR | P06213 | 1/20 | 0.49 |
| ▸ | LYN | P07948 | 1/20 | 0.49 |
| ▸ | HCK | P08631 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | ARAF | P10398 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4789348 | 0.92 | CSF1R (0.68) | CSF1RABL1BRAFEGFRKDR | |
| SCHEMBL4788124 | 0.84 | ABL1 (0.59) | CSF1RABL1BRAFEGFRLYN | |
| SCHEMBL4789584 | 0.82 | CSF1R (0.57) | CSF1RABL1BRAFEGFRLYN | |
| SCHEMBL4787030 | 0.80 | BRAF (0.61) | CSF1RABL1BRAFEGFRLCK | |
| SCHEMBL4789367 | 0.79 | ABL1 (0.56) | CSF1RABL1BRAFEGFRLYN | |
| SCHEMBL4789207 | 0.78 | ABL1 (0.55) | CSF1RABL1BRAFEGFRKDR | |
| SCHEMBL4788636 | 0.78 | EPHB2 (0.59) | CSF1RABL1BRAFKDRLCK | |
| SCHEMBL4788129 | 0.78 | BRAF (0.67) | CSF1RABL1BRAFEGFRKDR | |
| SCHEMBL4789587 | 0.76 | CSF1R (0.68) | CSF1RABL1BRAFEGFRLYN | |
| SCHEMBL4788536 | 0.73 | LCK (0.46) | CSF1RBRAFKDRLCKMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | claimed |
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |