Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 3/20 | 0.56 |
| ▸ | BRAF | P15056 | 11/20 | 0.56 |
| ▸ | EGFR | P00533 | 5/20 | 0.56 |
| ▸ | HCK | P08631 | 1/20 | 0.47 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.47 |
| ▸ | BTK | Q06187 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 4/20 | 0.47 |
| ▸ | LYN | P07948 | 2/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.46 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4789207 | 0.93 | ABL1 (0.55) | ABL1BRAFEGFRHCKNR2C2 | |
| SCHEMBL4789368 | 0.92 | BRAF (0.60) | ABL1BRAFEGFRHCKCSF1R | |
| SCHEMBL4788124 | 0.92 | ABL1 (0.59) | ABL1BRAFEGFRHCKNR2C2 | |
| SCHEMBL4789584 | 0.88 | CSF1R (0.57) | ABL1BRAFEGFRHCKNR2C2 | |
| SCHEMBL4789210 | 0.85 | BRAF (0.59) | ABL1BRAFEGFRHCKCSF1R | |
| SCHEMBL4788129 | 0.84 | BRAF (0.67) | ABL1BRAFEGFRHCKNR2C2 | |
| SCHEMBL4788636 | 0.84 | EPHB2 (0.59) | ABL1BRAFHCKNR2C2BTK | |
| SCHEMBL4789587 | 0.80 | CSF1R (0.68) | ABL1BRAFEGFRCSF1RLYN | |
| SCHEMBL4787030 | 0.80 | BRAF (0.61) | ABL1BRAFEGFRCSF1RKIT | |
| SCHEMBL4789345 | 0.79 | CSF1R (0.58) | ABL1BRAFEGFRHCKBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | claimed |
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |