Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 10/20 | 0.68 |
| ▸ | ABL1 | P00519 | 2/20 | 0.57 |
| ▸ | BRAF | P15056 | 6/20 | 0.56 |
| ▸ | LYN | P07948 | 2/20 | 0.56 |
| ▸ | RAF1 | P04049 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 2/20 | 0.55 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.52 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4789584 | 0.92 | CSF1R (0.57) | CSF1RABL1BRAFLYNRAF1 | |
| SCHEMBL4788129 | 0.92 | BRAF (0.67) | CSF1RABL1BRAFLYNRAF1 | |
| SCHEMBL4789210 | 0.89 | BRAF (0.59) | CSF1RABL1BRAFLYNRAF1 | |
| SCHEMBL4789368 | 0.88 | BRAF (0.60) | CSF1RABL1BRAFLYNRAF1 | |
| SCHEMBL14026977 | 0.86 | CSF1R (0.53) | CSF1RABL1BRAFLYNRAF1 | |
| SCHEMBL4788638 | 0.84 | CSF1R (0.69) | CSF1RABL1BRAFLYNRAF1 | |
| SCHEMBL4788124 | 0.83 | ABL1 (0.59) | CSF1RABL1BRAFLYNRAF1 | |
| SCHEMBL4789348 | 0.82 | CSF1R (0.68) | CSF1RABL1BRAFLYNRAF1 | |
| SCHEMBL4789207 | 0.81 | ABL1 (0.55) | CSF1RABL1BRAFLYNRAF1 | |
| SCHEMBL4787038 | 0.81 | BRAF (0.74) | CSF1RABL1BRAFRAF1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | claimed |
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |