Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.55 |
| ▸ | BRAF | P15056 | 14/20 | 0.55 |
| ▸ | EGFR | P00533 | 2/20 | 0.55 |
| ▸ | HCK | P08631 | 2/20 | 0.49 |
| ▸ | LYN | P07948 | 2/20 | 0.49 |
| ▸ | INSR | P06213 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.47 |
| ▸ | BTK | Q06187 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 3/20 | 0.47 |
| ▸ | CSF1R | P07333 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4789367 | 0.93 | ABL1 (0.56) | ABL1BRAFEGFRHCKLYN | |
| SCHEMBL4789210 | 0.92 | BRAF (0.59) | ABL1BRAFEGFRHCKLYN | |
| SCHEMBL4788124 | 0.92 | ABL1 (0.59) | ABL1BRAFEGFRHCKLYN | |
| SCHEMBL4789584 | 0.90 | CSF1R (0.57) | ABL1BRAFEGFRHCKLYN | |
| SCHEMBL4789368 | 0.85 | BRAF (0.60) | ABL1BRAFEGFRHCKLYN | |
| SCHEMBL4788673 | 0.84 | MAP3K7 (0.45) | BRAFHCKLYNINSRLCK | |
| SCHEMBL4788129 | 0.83 | BRAF (0.67) | ABL1BRAFEGFRHCKLYN | |
| SCHEMBL4788636 | 0.83 | EPHB2 (0.59) | ABL1BRAFHCKLYNLCK | |
| SCHEMBL4789587 | 0.81 | CSF1R (0.68) | ABL1BRAFEGFRLYNRAF1 | |
| SCHEMBL4787030 | 0.81 | BRAF (0.61) | ABL1BRAFEGFRLCKSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | claimed |
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |