Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 15/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 14/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | SPR | P35270 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24813930 | 0.77 | NFE2L2 (0.52) | NFE2L2KEAP1MEN1KMT2AUSP2 | |
| SCHEMBL826414 | 0.75 | NFE2L2 (0.54) | NFE2L2KEAP1MEN1KMT2AUSP2 | |
| SCHEMBL3678140 | 0.72 | NFE2L2 (0.58) | NFE2L2KEAP1MEN1KMT2AUSP2 | |
| SCHEMBL20378225 | 0.72 | KEAP1 (0.54) | NFE2L2KEAP1MEN1KMT2AUSP2 | |
| SCHEMBL27680970 | 0.69 | KMT2A (0.56) | NFE2L2KEAP1MEN1KMT2AUSP2 | |
| SCHEMBL27549598 | 0.69 | NFE2L2 (0.54) | NFE2L2KEAP1MEN1KMT2AUSP2 | |
| SCHEMBL21816266 | 0.68 | NFE2L2 (0.52) | NFE2L2KEAP1MEN1KMT2AUSP2 | |
| SCHEMBL4717984 | 0.68 | NFE2L2 (0.52) | NFE2L2KEAP1MEN1KMT2AUSP2 | |
| SCHEMBL21893929 | 0.67 | KEAP1 (0.51) | NFE2L2KEAP1MEN1KMT2AUSP2 | |
| SCHEMBL23732641 | 0.67 | KEAP1 (0.42) | NFE2L2KEAP1MEN1KMT2AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1999114-A2 | PYRAZOLES AS 11-BETA-HSD-1 | F. Hoffmann-la Roche AG (CH) | 2008-12-10 | — | — | EP | disclosed |
| WO-2007107470-A2 | PYRAZOLES AS 11-BETA-HSD-1 | F. HOFFMANN-LA ROCHE AG (CH) | 2007-09-27 | — | — | WO | disclosed |