Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 4/20 | 0.52 |
| ▸ | GPR142 | Q7Z601 | 8/20 | 0.46 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL807044 | 0.82 | RYR2 (0.58) | RIPK1GPR142CREBBPRYR2ESR1 | |
| SCHEMBL806996 | 0.80 | RYR2 (0.60) | RIPK1GPR142CREBBPRYR2MTNR1A | |
| SCHEMBL10069970 | 0.80 | AKR1C3 (0.55) | RIPK1GPR142CREBBPRYR2 | |
| SCHEMBL10069977 | 0.79 | RYR2 (0.61) | RIPK1GPR142CREBBPRYR2TP53 | |
| SCHEMBL8248116 | 0.77 | RYR2 (0.69) | RYR2 | |
| SCHEMBL10069978 | 0.77 | RYR2 (0.62) | RIPK1GPR142CREBBPRYR2 | |
| SCHEMBL19657617 | 0.75 | RIPK1 (0.64) | RIPK1CREBBPESR2TP53MAPT | |
| SCHEMBL30405260 | 0.74 | RIPK1 (0.48) | RIPK1ABHD6CREBBPESR2 | |
| SCHEMBL13765601 | 0.74 | RIPK1 (0.48) | RIPK1CREBBPESR2 | |
| SCHEMBL856288 | 0.74 | RIPK1 (0.48) | RIPK1ABHD6CREBBPESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144483-A2 | AGENTS FOR TREATING DISORDERS INVOLVING MODULATION OF RYANODINE RECEPTORS | ARMGO PHARMA, INC. (US) | 2008-11-27 | — | — | WO | disclosed |
| WO-2008144483-A2 | AGENTS FOR TREATING DISORDERS INVOLVING MODULATION OF RYANODINE RECEPTORS | ARMGO PHARMA, INC. (US) | 2008-11-27 | — | — | WO | disclosed |