Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RYR2 | Q92736 | 5/20 | 0.58 |
| ▸ | RIPK1 | Q13546 | 4/20 | 0.54 |
| ▸ | GPR142 | Q7Z601 | 8/20 | 0.50 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL806996 | 0.90 | RYR2 (0.60) | RYR2RIPK1GPR142CREBBPMTNR1A | |
| SCHEMBL10069970 | 0.85 | AKR1C3 (0.55) | RYR2RIPK1GPR142CREBBP | |
| SCHEMBL10070995 | 0.84 | RIPK1 (0.48) | RYR2RIPK1GPR142ESR1ESR2 | |
| SCHEMBL10069977 | 0.84 | RYR2 (0.61) | RYR2RIPK1GPR142CREBBP | |
| SCHEMBL4789441 | 0.82 | RIPK1 (0.52) | RYR2RIPK1GPR142CREBBPESR1 | |
| SCHEMBL10069978 | 0.82 | RYR2 (0.62) | RYR2RIPK1GPR142CREBBP | |
| SCHEMBL807157 | 0.81 | RIPK1 (0.45) | RYR2RIPK1GPR142 | |
| SCHEMBL807151 | 0.77 | RIPK1 (0.47) | RYR2RIPK1GPR142CREBBPESR1 | |
| SCHEMBL6439080 | 0.77 | PKM (0.48) | RYR2RIPK1GPR142MTNR1A | |
| SCHEMBL807141 | 0.76 | RYR2 (0.61) | RYR2ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037105-A1 | METHODS OF TREATING, AMELIORATING OR PREVENTING STRESS-INDUCED NEURONAL DISORDERS AND DISEASES | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2012-03-22 | — | — | WO | disclosed |
| WO-2012019076-A1 | COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING CARDIAC ISCHEMIA/REPERFUSION INJURY | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2012-02-09 | — | — | WO | disclosed |
| WO-2012019071-A1 | METHODS OF PREVENTING AND TREATING SARCOPENIA | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2012-02-09 | — | — | WO | disclosed |
| WO-2008144483-A2 | AGENTS FOR TREATING DISORDERS INVOLVING MODULATION OF RYANODINE RECEPTORS | ARMGO PHARMA, INC. (US) | 2008-11-27 | — | — | WO | disclosed |