Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 4/20 | 0.43 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | SCN1A | P35498 | 1/20 | 0.36 |
| ▸ | SCN4A | P35499 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.36 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.36 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.36 |
| ▸ | XIAP | P98170 | 1/20 | 0.36 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.36 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL806685 | 0.86 | CYP3A4 (0.43) | RIPK1ACACBKMT2AMEN1ATM | |
| SCHEMBL10074953 | 0.78 | RIPK1 (0.46) | RIPK1SMN1; SMN2PRMT5WDR77 | |
| SCHEMBL10075222 | 0.78 | RIPK1 (0.46) | RIPK1SMN1; SMN2 | |
| SCHEMBL10070995 | 0.74 | RIPK1 (0.48) | RIPK1P2RY1EPHX2 | |
| SCHEMBL807151 | 0.73 | RIPK1 (0.47) | RIPK1 | |
| SCHEMBL10074955 | 0.73 | RIPK1 (0.47) | RIPK1P2RY1EPHX2 | |
| SCHEMBL14023336 | 0.73 | RIPK1 (0.48) | RIPK1P2RY1 | |
| SCHEMBL10070492 | 0.70 | RYR2 (0.46) | RIPK1KCNH2SCN9ASCN10AABL1 | |
| SCHEMBL10070490 | 0.70 | RIPK1 (0.44) | RIPK1KCNH2SCN9ASCN10AABL1 | |
| SCHEMBL30584100 | 0.68 | MAOA (0.36) | RIPK1ACACBKMT2AMEN1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144483-A2 | AGENTS FOR TREATING DISORDERS INVOLVING MODULATION OF RYANODINE RECEPTORS | ARMGO PHARMA, INC. (US) | 2008-11-27 | — | — | WO | disclosed |