Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TYMS | P04818 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL499370 | 0.64 | ASAH1 (0.35) | MAPTALDH1A1KDM4EHTTPDK2 | |
| SCHEMBL499002 | 0.62 | AKR1A1 (0.33) | MAPTALDH1A1KDM4EGAA | |
| SCHEMBL28249000 | 0.62 | PGR (0.46) | NPSR1ALDH1A1KDM4E | |
| SCHEMBL29908236 | 0.61 | RAB9A (0.60) | MAPT | |
| SCHEMBL13256446 | 0.61 | RAB9A (0.60) | MAPT | |
| SCHEMBL13256445 | 0.60 | TDP1 (0.58) | MAPT | |
| SCHEMBL13256453 | 0.60 | TDP1 (0.58) | MAPT | |
| SCHEMBL12661123 | 0.60 | TDP1 (0.58) | MAPT | |
| SCHEMBL29384887 | 0.60 | TDP1 (0.58) | MAPT | |
| SCHEMBL15923240 | 0.60 | TDP1 (0.58) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156816-A2 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2008-12-24 | — | — | WO | disclosed |