Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 10/20 | 0.60 |
| ▸ | EGFR | P00533 | 5/20 | 0.60 |
| ▸ | CSF1R | P07333 | 5/20 | 0.57 |
| ▸ | LYN | P07948 | 2/20 | 0.57 |
| ▸ | RAF1 | P04049 | 1/20 | 0.57 |
| ▸ | ABL1 | P00519 | 2/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | INSR | P06213 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | HCK | P08631 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4789210 | 0.93 | BRAF (0.59) | BRAFEGFRCSF1RLYNRAF1 | |
| SCHEMBL4789367 | 0.92 | ABL1 (0.56) | BRAFEGFRCSF1RLYNRAF1 | |
| SCHEMBL4788129 | 0.92 | BRAF (0.67) | BRAFEGFRCSF1RLYNRAF1 | |
| SCHEMBL4789587 | 0.88 | CSF1R (0.68) | BRAFEGFRCSF1RLYNRAF1 | |
| SCHEMBL4789207 | 0.85 | ABL1 (0.55) | BRAFEGFRCSF1RLYNRAF1 | |
| SCHEMBL4788124 | 0.84 | ABL1 (0.59) | BRAFEGFRCSF1RLYNRAF1 | |
| SCHEMBL4788638 | 0.83 | CSF1R (0.69) | BRAFEGFRCSF1RLYNRAF1 | |
| SCHEMBL3387657 | 0.81 | MAP3K7 (0.51) | BRAFCSF1RLYNRAF1MAPK14 | |
| SCHEMBL4789584 | 0.80 | CSF1R (0.57) | BRAFEGFRCSF1RLYNRAF1 | |
| SCHEMBL13878787 | 0.79 | BRAF (0.54) | BRAFEGFRCSF1RLYNRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | claimed |
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |