Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 9/20 | 0.59 |
| ▸ | EGFR | P00533 | 2/20 | 0.59 |
| ▸ | CSF1R | P07333 | 6/20 | 0.56 |
| ▸ | RAF1 | P04049 | 6/20 | 0.56 |
| ▸ | LYN | P07948 | 2/20 | 0.56 |
| ▸ | ABL1 | P00519 | 2/20 | 0.56 |
| ▸ | INSR | P06213 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | HCK | P08631 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4789368 | 0.93 | BRAF (0.60) | BRAFEGFRCSF1RRAF1LYN | |
| SCHEMBL4789207 | 0.92 | ABL1 (0.55) | BRAFEGFRCSF1RRAF1LYN | |
| SCHEMBL4788129 | 0.92 | BRAF (0.67) | BRAFEGFRCSF1RRAF1LYN | |
| SCHEMBL4789587 | 0.89 | CSF1R (0.68) | BRAFEGFRCSF1RRAF1LYN | |
| SCHEMBL4788677 | 0.86 | CSF1R (0.56) | BRAFCSF1RRAF1LYNINSR | |
| SCHEMBL4789367 | 0.85 | ABL1 (0.56) | BRAFEGFRCSF1RRAF1LYN | |
| SCHEMBL4788124 | 0.83 | ABL1 (0.59) | BRAFEGFRCSF1RRAF1LYN | |
| SCHEMBL4788638 | 0.83 | CSF1R (0.69) | BRAFEGFRCSF1RRAF1LYN | |
| SCHEMBL4789584 | 0.81 | CSF1R (0.57) | BRAFEGFRCSF1RRAF1LYN | |
| SCHEMBL3387002 | 0.81 | LYN (0.55) | BRAFCSF1RRAF1LYNINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | claimed |
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |