Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 2/20 | 0.39 |
| ▸ | BMX | P51813 | 6/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | BRAF | P15056 | 3/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4789713 | 0.91 | BMX (0.41) | METBMXABL1SRCDDR1 | |
| SCHEMBL4789788 | 0.89 | BMX (0.46) | BMXABL1SRCDDR1MAPK14 | |
| SCHEMBL4789707 | 0.89 | BRAF (0.47) | BTKABL1JAK1BRAFJAK2 | |
| SCHEMBL4789712 | 0.88 | BMX (0.49) | BMXJAK1JAK2TYK2JAK3 | |
| SCHEMBL4788889 | 0.87 | BMX (0.53) | BTKBMXABL1SRCDDR1 | |
| SCHEMBL4789714 | 0.82 | BRAF (0.48) | BMXABL1SRCDDR1MAPK14 | |
| SCHEMBL4788641 | 0.82 | LCK (0.49) | METBMXABL1SRCDDR1 | |
| SCHEMBL4788852 | 0.81 | BRAF (0.43) | EGFRMETBMXABL1SRC | |
| SCHEMBL4788092 | 0.81 | BRAF (0.53) | BTKMAPK14BRAFJAK3 | |
| SCHEMBL14027871 | 0.80 | JAK1 (0.42) | JAK1BRAFJAK2TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | claimed |
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |