Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 7/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.46 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.45 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.45 |
| ▸ | BMX | P51813 | 3/20 | 0.45 |
| ▸ | CSF1R | P07333 | 2/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4789788 | 0.91 | BMX (0.46) | BRAFABL1SRCDDR1MAPK14 | |
| SCHEMBL4789710 | 0.91 | BRAF (0.52) | BRAFABL1SRCDDR1MAPK14 | |
| SCHEMBL4789715 | 0.90 | BMX (0.58) | BRAFMAPK14KCNK3KCNK9BMX | |
| SCHEMBL4789713 | 0.89 | BMX (0.41) | BRAFABL1SRCDDR1MAPK14 | |
| SCHEMBL4788891 | 0.89 | CSF1R (0.61) | BRAFABL1SRCDDR1MAPK14 | |
| SCHEMBL4788672 | 0.84 | LMNA (0.50) | BRAFABL1SRCDDR1MAPK14 | |
| SCHEMBL4788857 | 0.83 | BRAF (0.52) | BRAFABL1SRCDDR1MAPK14 | |
| SCHEMBL4788647 | 0.82 | LCK (0.46) | BRAFABL1SRCDDR1MAPK14 | |
| SCHEMBL4788095 | 0.82 | BRAF (0.63) | BRAFDDR1MAPK14DDR2CSF1R | |
| SCHEMBL4789786 | 0.82 | EGFR (0.43) | BRAFABL1SRCDDR1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | claimed |