Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 10/20 | 0.59 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.48 |
| ▸ | CDC7 | O00311 | 5/20 | 0.47 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.47 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 3/20 | 0.47 |
| ▸ | GSK3B | P49841 | 3/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
| ▸ | FLT3 | P36888 | 2/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.47 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.47 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.47 |
| ▸ | CIT | O14578 | 1/20 | 0.47 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4789857 | 0.85 | PDPK1 (0.58) | ROCK1PDPK1CYP3A4CDK2GSK3B | |
| SCHEMBL13306445 | 0.84 | PDPK1 (0.53) | ROCK1PDPK1CYP3A4CDC7CDK2 | |
| SCHEMBL23163201 | 0.82 | ROCK1 (0.61) | ROCK1PDPK1CYP3A4CAMKK2CDK2 | |
| SCHEMBL4789520 | 0.81 | PDPK1 (0.58) | ROCK1PDPK1CDC7CDK2GSK3B | |
| SCHEMBL4789114 | 0.80 | ROCK1 (0.61) | ROCK1PDPK1CYP3A4GSK3BCDK5 | |
| SCHEMBL5112575 | 0.79 | ROCK1 (0.53) | ROCK1PDPK1CYP3A4CDC7CAMKK2 | |
| SCHEMBL4789558 | 0.78 | CYP3A4 (0.62) | ROCK1PDPK1CYP3A4CDK2GSK3B | |
| SCHEMBL23163147 | 0.76 | CDK9 (0.57) | ROCK1PDPK1CDC7DBF4CDK2 | |
| SCHEMBL23163163 | 0.76 | ROCK1 (0.55) | ROCK1PDPK1CYP3A4CDK2GSK3B | |
| SCHEMBL23163165 | 0.76 | ROCK1 (0.55) | ROCK1PDPK1CYP3A4CDK2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008011557-A2 | HETEROARYL INHIBITORS OF RHO KINASE | BORCHARDT ALLEN J (US) | 2008-01-24 | — | — | WO | disclosed |
| US-20080021217-A1 | HETEROCYCLIC INHIBITORS OF RHO KINASE | Borchardt, Allen (US) | 2008-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080021217-A1 | HETEROCYCLIC INHIBITORS OF RHO KINASE | ROCK1, ROCK2, RHOA | ROCK1 1/4885PDPK1 382/4885CYP3A4 4367/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.