Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 2/20 | 0.45 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.45 |
| ▸ | BRAF | P15056 | 11/20 | 0.45 |
| ▸ | CSF1R | P07333 | 3/20 | 0.45 |
| ▸ | LYN | P07948 | 2/20 | 0.45 |
| ▸ | RAF1 | P04049 | 2/20 | 0.45 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | INSR | P06213 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | HCK | P08631 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.41 |
| ▸ | CSK | P41240 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4788677 | 0.91 | CSF1R (0.56) | MAP3K7MAP4K2BRAFCSF1RLYN | |
| SCHEMBL4788870 | 0.84 | KMT2A (0.60) | MAP3K7MAP4K2BRAFLYNRAF1 | |
| SCHEMBL4788930 | 0.84 | MAPK14 (0.53) | MAP3K7MAP4K2CSF1RRAF1KMT2A | |
| SCHEMBL4789207 | 0.84 | ABL1 (0.55) | BRAFCSF1RLYNRAF1INSR | |
| SCHEMBL4789920 | 0.84 | KDR (0.44) | BRAFCSF1RRAF1DDR1LCK | |
| SCHEMBL14026838 | 0.83 | BRAF (0.66) | MAP3K7MAP4K2BRAFCSF1RLYN | |
| SCHEMBL4788889 | 0.82 | BMX (0.53) | BRAFCSF1RRAF1DDR1ATM | |
| SCHEMBL4788872 | 0.79 | DDR1 (0.70) | MAP3K7MAP4K2BRAFLYNRAF1 | |
| SCHEMBL4789367 | 0.78 | ABL1 (0.56) | MAP3K7MAP4K2BRAFCSF1RLYN | |
| SCHEMBL4788852 | 0.77 | BRAF (0.43) | BRAFRAF1DDR1LCKSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |