Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.53 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.53 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.53 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.53 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.52 |
| ▸ | RAF1 | P04049 | 1/20 | 0.51 |
| ▸ | NR2E1 | Q9Y466 | 6/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HCK | P08631 | 1/20 | 0.49 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.49 |
| ▸ | BTK | Q06187 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | BCR | P11274 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4788935 | 0.91 | CSF1R (0.63) | MAPK14MAP3K20MAP3K7MAP4K2EPHB2 | |
| SCHEMBL4787135 | 0.88 | MAP3K7 (0.61) | MAPK14MAP3K20MAP3K7MAP4K2EPHB2 | |
| SCHEMBL4789920 | 0.86 | KDR (0.44) | MAPK14RAF1CSF1RBTKABL1 | |
| SCHEMBL4788889 | 0.84 | BMX (0.53) | MAPK14RAF1CSF1RMAPTBTK | |
| SCHEMBL4788673 | 0.84 | MAP3K7 (0.45) | MAPK14MAP3K20MAP3K7MAP4K2RAF1 | |
| SCHEMBL4788636 | 0.83 | EPHB2 (0.59) | MAPK14MAP3K20MAP3K7MAP4K2EPHB2 | |
| SCHEMBL4788852 | 0.80 | BRAF (0.43) | MAPK14RAF1ABL1 | |
| SCHEMBL4788092 | 0.79 | BRAF (0.53) | MAPK14RAF1BTK | |
| SCHEMBL4787141 | 0.78 | CSF1R (0.67) | MAPK14MAP3K20MAP3K7MAP4K2EPHB2 | |
| SCHEMBL4789921 | 0.78 | KDR (0.48) | MAPK14RAF1CSF1RABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |