Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ACLY | P53396 | 2/20 | 0.34 |
| ▸ | F13A1 | P00488 | 1/20 | 0.34 |
| ▸ | TGM2 | P21980 | 1/20 | 0.34 |
| ▸ | TGM1 | P22735 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 2/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4651960 | 0.73 | ALDH1A1 (0.49) | ALDH1A1MAPTHPGDKMT2ALMNA | |
| SCHEMBL2526014 | 0.72 | ALDH1A1 (0.36) | KDM4EALDH1A1GAAMAPTHPGD | |
| SCHEMBL4790217 | 0.72 | ALDH1A1 (0.34) | ALDH1A1MAPTHPGDF13A1TGM2 | |
| SCHEMBL2529528 | 0.71 | ALDH1A1 (0.38) | ALDH1A1MAPTMEN1HPGDKMT2A | |
| SCHEMBL4874190 | 0.69 | SMN1; SMN2 (0.38) | ALDH1A1MAPTHPGDMCL1LMNA | |
| SCHEMBL3081849 | 0.67 | HCAR2 (0.47) | ALDH1A1MAPTMEN1HPGDKMT2A | |
| SCHEMBL2527725 | 0.67 | MAPT (0.40) | KDM4EALDH1A1GAAMAPTHPGD | |
| SCHEMBL15375412 | 0.67 | HCAR2 (0.42) | ALDH1A1MAPTHPGDKMT2ATGM2 | |
| SCHEMBL2531116 | 0.64 | KMT2A (0.38) | KDM4EALDH1A1GAAMAPTMEN1 | |
| SCHEMBL2526958 | 0.64 | ALDH1A1 (0.41) | ALDH1A1MAPTMEN1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968954-A1 | MACROCYCLIC COMPOUNDS USEFUL AS BACE INHIBITORS | Novartis AG (CH) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007077004-A1 | MACROCYCLIC COMPOUNDS USEFUL AS BACE INHIBITORS | NOVARTIS AG (CH) | 2007-07-12 | — | — | WO | disclosed |